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Most k2 synthetic cannabinoids are agonists of the cannabinoid receptors. These synthetic analogs often have greater binding affinity and greater potency to the CB1 receptors. There are several synthetic cannabinoid families which are classified by the creator of the substance (e.g. JWH stands for John W. Huffman), which can include several substances with different base structures such as classical cannabinoids and unrelated naphthoylindoles.
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Reported user negative effects include palpitations, paranoia, intense anxiety, nausea, vomiting, confusion, poor coordination, and seizures. There have also been reports of a strong compulsion to re-dose, withdrawal symptoms, and persistent cravings. Severe illnesses and death have resulted from this contamination.
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ADB-BUTINACA (ADB-BINACA) is a new synthetic cannabinoid that was first found in Europe in 2019. Although National Forensic Service (NFS) also identified it in authentic seizures from early last year, it was unable to test biological samples due to the unavailability of metabolic data with the absence of reference standards. NFS finally established the method of detection in biological samples.