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Most synthetic cannabinoids are agonists of the cannabinoid receptors. They have been designed to be similar to THC the natural cannabinoid with the strongest binding affinity to the CB1 receptor, which is linked to the psychoactive effects or “high” of marijuana.

These synthetic analogs often have greater binding affinity and greater potency to the CB1 receptors. There are several synthetic cannabinoid families classified based on the base structure

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